Jurgen Klopp is without his first-choice central defenders and captain, while Alisson is absent on compassionate grounds. Liverpool start the game in sixth, five points outside the top four.
Fifth host second, with six points between the teams at kickoff. Hakim Ziyech starts for Chelsea -- Christian Pulisic is a sub -- while Daniel James and Mason Greenwood are in the United XI.
Leicester City and Arsenal return from Europa League duty at the King Power Stadium. The Foxes can climb to second, while Arsenal need to make ground on the European places.