Sadio Mane is the latest Liverpool player to suffer an injury, with Jordan Henderson and young Nathaniel Phillips the only fit centre-backs to travel to east London to face West Ham.
Chelsea's second game under new manager Thomas Tuchel sees underfire striker Timo Werner given a chance to impress against Burnley. Follow live with ESPN.
To be the best, you must beat the best. Not for the first time, though, Man United failed to take their chances against big-six rivals; a goalless draw at Arsenal further dents their title hopes.