Bruno Fernandes and Marcus Rashford are in the line-up for the last-32 first leg, which takes place in Italy. Adnan Januzaj, once of United, and Man City legend David Silva start for La Real.
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Chilean side Colo-Colo avoided relegation for the first time in the club's 96-year history with a 1-0 win at Universidad Concepcion.
This week brought news of some high-profile moves in Germany, and Derek Rae explains why the Bundesliga has seen so little handwringing over them.
Adidas' latest Predator and Copa boot lines are cool, but what are the weirdest design concepts around?
Former Arsenal manager Arsene Wenger said UEFA's proposed changes to the Champions League do not respect the "sporting merit" of the competition.
Crystal Palace winger Wilfried Zaha has said that taking a knee before every game is "degrading" and called for tangible change.
Man City are on top of the Premier League, but only after overcoming their shortcomings -- something their title rivals have been unable to do.
Arsenal will continue wholesale changes as Alexandre Lacazette are set to leave while Dani Ceballos will on stay. Transfer Talk has the latest.
MLS and the New York Red Bulls are taking the contract dispute involving midfielder Kaku to arbitration.
Porto scored in the opening minutes of both halves but Juventus grabbed a crucial away goal as the Portuguese side beat the Italian champions 2-1.
Erling Haaland said Kylian Mbappe's hat-trick for Paris Saint-Germain against Barcelona on Tuesday gave the Borussia Dortmund striker "motivation."
Erling Haaland scored twice as Borussia Dortmund overcame an early deficit to beat Sevilla in their Champions League last-16 first leg on Wednesday.
U.S. women's national team manager Vlatko Andonovski said star forward Alex Morgan is approaching top form ahead of the upcoming SheBelieves Cup.
Six other clubs topped the table earlier this season in a then-thrilling title race. Man City have ended all that, now 10 points clear at the top.
The 2021 SheBelieves Cup should be easy for the USWNT, with Alex Morgan & Co. fit again. The goal is prepping for the Olympics... if they happen.
Barcelona's La Masia is soccer's most famous academy, but Benfica is really where many of the game's greats grow up before joining elite teams.
Cristiano Ronaldo goes back to Portugal as Juventus take on Porto, while Dortmund face Europa League winners Sevilla. Meanwhile, in the Premier League, leaders Man City visit Everton.
Chelsea Clinton and Jenna Bush Hager are part of a group investing in the NWSL's Washington Spirit, the team said on Wednesday.
The footballers said they would offer support to anyone struggling with a decision to come out in public and defend them in the face of hostility.
LA Galaxy have completed the signing of Mexican teenage prodigy Alex Alcala, the club announced.
