Christian Pulisic scored as Chelsea claimed a 2-1 victory away to Lille on Wednesday to advance to the Champions League quarterfinals.
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There is plenty on the line at the Emirates Stadium, with fourth-place chasing Arsenal taking on Liverpool, who will move within one of leaders Manchester City with a victory.
Axel Witsel scored an 87th-minute goal to give Borussia Dortmund a 1-0 victory at Mainz as they closed in to within four points of Bayern Munich.
Boca Juniors and River Plate remain Argentina's marquee clubs but can either side challenge Brazilian clubs' recent Copa Libertadores dominance?
Marcus Rashford has hit out at abuse he has received after a video showed the Manchester United star in a verbal altercation with a fan on Tuesday.
Why did PSG fans heckle Messi last weekend? It's complicated, as the relationship between club and hardcore support has always been.
Expansion team Angel City will host the North Carolina Courage for its first ever regular season game as the NWSL revealed its 2022 schedule.
The RSPCA has said it has begun prosecution proceedings against West Ham United's Kurt Zouma after a video emerged last month of him kicking a cat.
St. Louis City SC announced the signing Wednesday of Swiss goalkeeper Roman Burki to a three-year contract.
From the start, Xherdan Shaqiri didn't seem to fit in Lyon. Six months later, he left for Chicago, and the early returns in MLS are encouraging.
Cristiano Ronaldo is set for his first season without at least one piece of silverware since 2009-10. How does that compare to other top players?
Karim Benzema will be tried in court after his appeal against being found guilty of "complicity" in the sex-tape case against Mathieu Valbuena.
UCLA law professor Steven Bank evaluates why the USWNT and U.S. Soccer would announce an equal pay settlement before it's finalized.
The owners of Major League Baseball team Chicago Cubs and Citadel chief executive Ken Griffin are set to table a joint bid for Chelsea.
FIFA's Gianni Infantino believes a "strong commitment" to ensure labour reforms are fully implemented is being shown by the government in Qatar.
Manchester United have launched an investigation to identify the fans who threw objects at Atletico Madrid boss Diego Simeone, sources told ESPN.
Who is good enough to replace Erling Haaland once he leaves Dortmund? Norwegian football scout Tor-Kristian Karlsen surveys the options.
New York City FC advanced to the CONCACAF Champions League semifinals despite a 4-2 loss to Comunicaciones FC on Tuesday in Guatemala City.
Man United have become a club that drains the talent out of their best players and, as Tuesday's Champions League elimination proved, nothing will be won until that changes.
David De Gea has said Manchester United are "far away" from challenging for big trophies after losing to Atletico Madrid in the Champions League.
